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蛋氨酸腺苷转移酶2A
配景
蛋氨酸腺苷转移酶2A（MAT2A）是蛋氨酸循环中的一种限速酶，同时也是被公认的癌症治疗靶点。目前果真报道了许多MAT2A抑制剂，有三种已经进入临床试验阶段，用以治疗甲基硫腺苷磷酸化酶（MTAP）缺失导致的实体瘤或淋巴瘤。辉瑞、阿斯利康、Agios等诸多药企都针对该靶点进行过抑制剂的开发。
实验结果
单体的MAT2A酶不可进行催化作用，因为该卵白在单体状态下无法形成完整的活性位点。形成二聚体后，卵白的两个单体各自孝敬出一半残基形成完整的活性位点。想要针对MAT2A靶点筛选抑制剂，需要获得贴近人体内情况的，形成二聚体的卵白。
我们用通例的原核卵白表达系统，表达出单体MAT2A卵白（图一）。
图一 MAT2A单体表达纯化结果
同时通过昆虫表达系统，乐成获得了二聚体MAT2A卵白（图二）。
图二 MAT2A二聚体表达纯化结果
图三 MAT2A单体和二聚体分子筛结果
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[ BEHAVIOR ] Run Closure @app_init [ RunTime:0.000398s ]
[ BEHAVIOR ] Run app\common\behavior\Common @app_init [ RunTime:0.000399s ]
[ LANG ] /www/wwwroot/readcrystal.com/wwwroot/thinkphp/lang/zh-cn.php
[ BEHAVIOR ] Run app\common\behavior\Common @app_dispatch [ RunTime:0.000014s ]
[ ROUTE ] array ( 'type' => 'method', 'method' => array ( 0 => '\\think\\addons\\Route', 1 => 'execute', ), 'var' => array ( 'addon' => 'cms', 'controller' => 'archives', 'action' => 'index', ), )
[ HEADER ] array ( 'cookie' => '_vstime=1685295721', 'referer' => '/', 'accept' => '*/*', 'user-agent' => 'Mozilla/4.0 (compatible; MSIE 8.0; Windows NT 5.2)', 'host' => 'www.readcrystal.com', 'content-length' => '', 'content-type' => '', )
[ PARAM ] array ( 'catename' => 'dbbd', 'diyname' => '213', )
[ RUN ] think\addons\Route->execute[ /www/wwwroot/readcrystal.com/wwwroot/vendor/karsonzhang/fastadmin-addons/src/addons/Route.php ]
[ LANG ] /www/wwwroot/readcrystal.com/wwwroot/public/../application/common/lang/zh-cn/addon.php
[ BEHAVIOR ] Run app\common\behavior\Common @addon_begin [ RunTime:0.001067s ]
[ LANG ] /www/wwwroot/readcrystal.com/wwwroot/addons/cms/lang/zh-cn.php
[ BEHAVIOR ] Run \addons\alioss\Alioss @upload_config_init [ RunTime:0.000178s ]
[ DB ] INIT mysql
[ VIEW ] /www/wwwroot/readcrystal.com/wwwroot/addons/cms/view/theme/show_case.html [ array ( 0 => 'config', 1 => 'user', 2 => 'site', 3 => '__CHANNEL__', 4 => 'isWechat', 5 => '__ARCHIVES__', 6 => '__MODEL__', ) ]
[ SESSION ] INIT array ( 'id' => '', 'var_session_id' => '', 'prefix' => 'think', 'type' => '', 'auto_start' => true, )
[ BEHAVIOR ] Run \addons\cms\Cms @view_filter [ RunTime:0.000097s ]
0.114667s
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